Dimethylformamide dimethyl acetal → 8-Chloro-4-((dimethylamino)methylene)-1-(3-(1,3-dioxoisoindolin-2-yl)propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide dimethyl acetal	HCID 78373	—
Reactant	8-chloro-1-(3-(1,3-dioxoisoindolin-2-yl)propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione	HCID 59852157	—
Product	8-Chloro-4-((dimethylamino)methylene)-1-(3-(1,3-dioxoisoindolin-2-yl)propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione	HCID 66934792	—

Reaction Steps

In a manner similar to that described for method G, 8-chloro-1-(3-(1,3-dioxoisoindolin-2-yl)propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (I-40-a) and DMF-DMA were converted to I-40-b and carried on crude: MS m/z═452 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07459448B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-50bfc92bd80a43a3b3e666fe80ad643f
Source note	uspto-grants-2008_12