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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2373453Generated: October 26, 2026

Ethyl 5-bromopicolinate → 5-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-pyridine-2-carboxylic acid ethyl ester

https://huagongshe.com/reaction/2373453

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-bromopicolinateHCID 12686158—
Reactant7-Ethynyl-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepineHCID 59852695—
Product5-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-pyridine-2-carboxylic acid ethyl esterHCID 11450984—

Reaction Steps

The title compound is prepared in analogy to example 1 from 7-ethynyl-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine (6) (example 1d) and 5-bromo-pyridine-2-carboxylic acid ethyl ester (22) as a gum. MS (ESI) 351.1 (M•)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07459480B2
Source datasetuspto-grants-2008_12
ORD IDord-6a306820180845aea796a60af8786046
Source noteuspto-grants-2008_12