HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 59852694, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Ammonium Bromide | HCID 25514 | — |
| Reactant | HCID 178506543 | HCID 178506543 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 59852694 | HCID 59852694 | — |
Reaction Steps
A mixture of 5-(4-iodo-phenyl)-1H-tetrazole (24) (500 mg) and ammonium bromide (1.18 g) in 1 N aq. NaOH sol. (10 ml) and CH2Cl2 (10 ml) is treated with iodomethane and vigorously stirred 26 h at RT. The organic layer is separated, washed with 1 N aq. NaOH sol., aq. NH4Cl sol. and brine. After drying over MgSO4 the solvent is evaporated and the product is purified by flash chromatography (silica gel, heptane/CH2Cl2 1:1 to pure CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459480B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-f81c87921072496e9cdaef6390406990 |
| Source note | uspto-grants-2008_12 |