HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-[(4-Iodophenyl)carbonyl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Iodobenzoyl chloride | HCID 74373 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(4-Iodophenyl)carbonyl]morpholine | HCID 772634 | 81.2% |
Reaction Steps
A mixture of 4-iodobenzoyl chloride (500 mg), morpholine (163 mg) and triethylamine (380 mg) in CH2Cl2 (20 ml) is stirred 2 h before washing with H2O (20 ml) and brine (20 ml). The organic layer is dried over MgSO4 and the solvent is evaporated to obtain 482 mg of (4-iodo-phenyl)-morpholin-4-yl-methanone, yellowish semisolid, MS (ESI) 318.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459480B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-d9c8d5e6cc104516aeefc75445902a88 |
| Source note | uspto-grants-2008_12 |