Ethylparaben → HCID 11175714, compound

Participants

Reaction Steps

To a mixture of (3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methanol (31) (100 mg), polymer bound PPh3 (412 mg, ˜3 mmol/g on polystyrene) and ethyl-4-hydroxybenzoate in CH2Cl2 (4 ml) is added di-tert-butylazodicarboxylate (111 mg). The mixture is shaken 1 h, then the polymer is filtered off and the solvent is evaporated. Flash chromatography yields 74 mg of 4-(3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylmethoxy)-benzoic acid ethyl ester as a colourless oil, MS (ESI) 357.2 (M+H)+.

Provenance & Evidence