反应详情

(4-Bromophenyl)(4′-fluorophenyl)methanone (formula 28) (400 g, 1.43 mol) from Example 4A and anhydrous nickel bromide (35 g, 0.16 mol) are heated to 160° C. under an atmosphere of nitrogen. A green-blue colored melt is obtained. Then triethyl phosphite (304 g, 1.83 mol) is added over a period of 1 hour while maintaining the temperature between 160 and 165° C. The mixture is stirred at this temperature for an additional hour. Distillation of the mixture gave a pale yellow oil, b.p. 187-188° C./10-2 mbar. The yield is 304-326 g (63-68%).

1. customA green-blue colored melt is obtained
2. temperaturewhile maintaining the temperature between 160 and 165° C
3. distillationDistillation of the mixture
4. customgave a pale yellow oil, b.p. 187-188° C./10-2 mbar