HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2373520Generated: October 30, 2026
Triethylamine → Phenylmethyl 1-cyano-7-azabicyclo[2.2.1]heptane-7-carboxylate
https://huagongshe.com/reaction/2373520
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | HCID 21112383 | HCID 21112383 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Phenylmethyl 1-cyano-7-azabicyclo[2.2.1]heptane-7-carboxylate | HCID 21112384 | — |
Reaction Steps
Benzyl 1-(aminocarbonyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate (C-36) in dichloromethane was treated at 0° C. with Et3N (2.1 eq.) and trifluoroacetic anhydride (1.1 eq.) was added dropwise. The reaction mixture was stirred at 0° C. for 30 minutes. Then, it was diluted with dichloromethane, washed with saturated NaHCO3 solution, H2O, brine and dried over Na2SO4. Filtration and evaporation afforded the titled compound (C-37).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07459452B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-16c327d279d74786a668576c1ffedb8a |
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| Source note | uspto-grants-2008_12 |
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