HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 1-(3-Aminophenyl)2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Bromo-1-(3-nitrophenyl)ethan-1-one | HCID 75213 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-Methyl-5-piperazin-1-yl-quinoline | HCID 49851901 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(3-Aminophenyl)2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethanol | HCID 57444281 | — |
Reaction Steps
Sodium carbonate (1.5 eq) and 2-bromo-1-(3-nitrophenyl)ethanone (1.5 eq) were added to a stirred solution of 2-methyl-5-(1-piperazinyl)quinoline (D3) (1 eq) in tetrahydrofuran at room temperature under an inert atmosphere, and the reaction was left under stirring for 1 h. The solution was then diluted with MeOH, NaBH4 (2 eq) was added and the reaction was left under stirring for 1 h. The solvent was removed under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459456B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-68de41b65ece419f89f10b1b56d836c2 |
| Source note | uspto-grants-2008_12 |