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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2373612Generated: October 26, 2026

4,5-Dichlorophthalic anhydride → 5,6-dichloro-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-isoindole-1,3(2H)-dione

https://huagongshe.com/reaction/2373612

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,5-Dichlorophthalic anhydrideHCID 70334—
Reactant3-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}anilineHCID 49852105—
Product5,6-dichloro-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-isoindole-1,3(2H)-dioneHCID 68425668—

Reaction Steps

Prepared from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 5,6-dichloro-2-benzofuran-1,3-dione according to Method I.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07459456B2
Source datasetuspto-grants-2008_12
ORD IDord-0b45275810b54115b903d3d895cdbf32
Source noteuspto-grants-2008_12