Dimethyl-1,3-thiazole-5-carboxylic acid → 2,4-Dimethyl-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Dimethyl-1,3-thiazole-5-carboxylic acid	HCID 736488	—
Reactant	3-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline	HCID 57444335	—
Product	2,4-Dimethyl-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide	HCID 57478356	87%

Reaction Steps

The title compound was prepared in 87% yield according to the general procedure for the preparation of amides (Method C) starting from 3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D21) and 2,4-dimethyl-1,3-thiazole-5-carboxylic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07459456B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-a451bf18c15a4c5f9dd550c84b386da9
Source note	uspto-grants-2008_12