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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2373628Generated: October 25, 2026

2-Methylpiperazine, (S)- → 2-Methyl-5-[(3S)-3-methyl-1-piperazinyl]quinoline

https://huagongshe.com/reaction/2373628

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methylpiperazine, (S)-HCID 2734219—
Reactant2-Methylquinolin-5-yl trifluoromethanesulfonateHCID 49851899—
Product2-Methyl-5-[(3S)-3-methyl-1-piperazinyl]quinolineHCID 5744434127%

Reaction Steps

The title compound was prepared in 27% yield using a similar procedure to Example 127 starting from (2S)-2-methylpiperazine and 2-methyl-5-quinolinyl trifluoromethanesulfonate (D1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07459456B2
Source datasetuspto-grants-2008_12
ORD IDord-65ba43a3001c4a1d8c9526efac7fa036
Source noteuspto-grants-2008_12