HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 1-[3-(2-Hydroxyethyl)phenyl]-2-pyrrolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | 2-(3-Bromophenyl)ethan-1-ol | HCID 2734090 | — |
| Product | 1-[3-(2-Hydroxyethyl)phenyl]-2-pyrrolidinone | HCID 57444361 | 15% |
Reaction Steps
The title compound was prepared in 15% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 2-(3-bromophenyl)ethanol and 2-pyrrolidinone. Purification was achieved by flash chromatography on silica gel eluting with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459456B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-80fa83eaeefd479bbf2a7189e5a601b2 |
| Source note | uspto-grants-2008_12 |