3-Methyl-2-pyrazolin-5-one → 5-methyl-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2,4-dihydro-3H-pyrazol-3-one

HRID 2373673Notes

Reaction equation

HRID 2373673 reaction equation
I[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]4)[CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[CH3:27][C:28]1[CH2:29][C:30](=[O:33])[NH:31][N:32]=1>>[CH3:27][C:28]1[CH2:29][C:30](=[O:33])[N:31]([C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][N:10]3[CH2:15][CH2:14][N:13]([C:16]4[CH:25]=[CH:24][CH:23]=[C:22]5[C:17]=4[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]5)[CH2:12][CH2:11]3)[CH:3]=2)[N:32]=1

Participants

3

Reactant 2

HCID 79203-Methyl-2-pyrazolin-5-oneHCID 574443555-{4-[2-(3-Iodophenyl)ethyl]-1-piperazinyl)2-methylquinoline

Product 1

HCID 574443755-methyl-2-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2,4-dihydro-3H-pyrazol-3-oneYield 58%

Procedure

The title compound was prepared in 58% yield according to the general procedure for the preparation of amides, ureas and carbamates (Method A) starting from 5-{4-[2-(3-iodophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and 5-methyl-2,4-dihydro-3H-pyrazol-3-one.

Sources & evidence

ORD record
ord-4736b655dd53406e953807320cc47192
Source dataset
uspto-grants-2008_12
Patent number
US07459456B2

Reaction notes

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