Menthol → (-)-Menthol

Participants

Reaction Conditions

Reaction Steps

54 g of crude menthol (content of (L)-menthol: 95.7%; optical purity: 97% e.e.; content of isomer of isomenthol: 2.5%; content of isomer of neoisomenthol: 1.8%; content of isomer of neomenthol: trace) was dissolved in 150 ml of acetonitrile at 30° C., and this solution was cooled to 5° C., followed by filtration to obtain 32 g of purified (L)-menthol. GC (gas chromatography) analysis revealed that no isomers (isomenthol, neoisomenthol, and neomenthol) were detected with the purified (L)-menthol.

Provenance & Evidence