HCID 14401625, compound → HCID 14454685, compound

Participants

Reaction Steps

A solution of 2.64 g (10 mmol) of 3-(4-hydroxy-3,5-diisopropylphenyl)propanoic acid methyl ester (cf. U.S. Pat. No. 3,642,868) and 0.84 g (20 mmol) of LiOH,H2O in 80 ml of a 1/1 mixture THF/H2O was stirred at 20° C. for 7 hours. After evaporation of THF under reduced pressure, the aqueous solution was acidified with KHSO4 (1M) and extracted twice with 50 ml EtOAc. The organic layer was decanted, washed with 20 ml brine, dried over MgSO4 and filtered. The residue of evaporation was triturated with heptane to yield a white powder (67%). Melting, point: 106-106.5° C.

Provenance & Evidence