HCID 68868338, compound → HCID 69208073, compound

HRID 2373789Notes

Reaction equation

HRID 2373789 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[CH:5][C:4]=1[C:19](O)=[O:20].[CH3:22][O:23][C:24](=[O:42])[C@H:25]([NH2:41])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][C:36]([F:39])=[C:35]([Cl:40])[CH:34]=2)=[CH:29][CH:28]=1>>[CH3:22][O:23][C:24](=[O:42])[C@H:25]([NH:41][C:19]([C:4]1[CH:5]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:18])[F:17])=[CH:11][CH:10]=2)[CH:7]=[CH:8][C:3]=1[O:2][CH3:1])=[O:20])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][C:36]([F:39])=[C:35]([Cl:40])[CH:34]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 68868338HCID 68868338, compoundHCID 69533155HCID 69533155, compound

Product 1

HCID 69208073HCID 69208073, compoundYield 76.1%

Procedure

3-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-2-(R)-[(4-methoxy-4′-trifluoromethyl-biphenyl-3-carbonyl)-amino]-propionic acid methyl ester (223 mg) was prepared from 4-Methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (141 mg, 0.5 mmol) and-2-(R)-amino-3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-propionic acid methyl ester (155 mg, 0.5 mmol) following the general procedure A.

Sources & evidence

ORD record
ord-7e78548bf34c49678045e9ba07c21b7e
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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