3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 4-Hydroxy-4'-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3'-chloro-4'-fluoro-6-methoxy-biphenyl-3-yl)-ethyl]-amide

Participants

Reaction Steps

The resin-bound 4-hydroxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (20 mg, 0.06 mmol) obtained as in Example 1 was reacted with 3-bromo-4-methoxy-phenethyl amine (57 mg, 0.25 mmol) following general procedure A to give resin bound 4-Hydroxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-3-bromo-4-methoxy-phenyl)-ethyl]-amide(18 mg, 0.05 mmol). The above resin bound amide was treated with 3-chloro-4-fluoro-phenyl boronic acid (43 mg, 0.25 mmol) as described in the general procedure D to provide the title compound (8.0 mg,).

Provenance & Evidence