反应详情

4-Amino-4′-trifluoromethyl-biphenyl-3-carboxylic acid methyl ester (3.0 g) was prepared from 2-amino-5-bromobenzoic acid methyl ester (4.58 g, 20 mmol) and 4-trifluoromethylphenyl boronic acid (4.75 g, 25 mmol) following general procedure D, then hydrolyzed following general procedure C. The above acid (281 mg, 1.0 mmol) was reacted with 2(S)-amino-3-(3′chloro-4′-fluoro-biphenyl-4-yl)-propionic acid methyl ester (343 mg, 1.0 mmol) as described in general procedure A to give the title compound. (300 mg)