HCID 86597141, compound → HCID 69205195, compound

HRID 2373798Notes

Reaction equation

HRID 2373798 reaction equation
FC1C([O:8][C:9](=O)[C@H:10]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[C:20]([Cl:25])[CH:19]=3)=[CH:14][CH:13]=2)=C(F)C(F)=C(F)C=1F.O[NH:40][C:41](=[NH:43])[CH3:42]>>[C:30]([O:29][C:27](=[O:28])[NH:26][C@@H:10]([C:9]1[O:8][N:43]=[C:41]([CH3:42])[N:40]=1)[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([Cl:25])[CH:19]=2)=[CH:16][CH:17]=1)([CH3:33])([CH3:31])[CH3:32]

Participants

3

Reactant 2

HCID 86597141HCID 86597141, compoundHCID 178465666HCID 178465666, compound

Product 1

HCID 69205195HCID 69205195, compoundYield 88.9%

Procedure

[2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamic acid tert-butyl ester (96 mg,) was prepared from 2-(R)-tert-butoxycarbonylamino-3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-propionic acid pentafluorophenyl ester (140 mg, 0.25 mmol) and N-hydroxy-acetamidine (37 mg, 0.5 mmol) following the general procedure O.

Sources & evidence

ORD record
ord-5ce7a065491c40c7ae1d9acecd205878
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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