HCID 68869955, compound → HCID 57717940, compound

HRID 2373800Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[CH:5][C:4]=1[C:19](Cl)=[O:20].[Cl:22][C:23]1[CH:24]=[C:25]([C:30]2[CH:35]=[CH:34][C:33]([CH2:36][C@@H:37]([NH2:44])[C:38]3[O:42][N:41]=[C:40]([CH3:43])[N:39]=3)=[CH:32][CH:31]=2)[CH:26]=[CH:27][C:28]=1[F:29]>>[Cl:22][C:23]1[CH:24]=[C:25]([C:30]2[CH:35]=[CH:34][C:33]([CH2:36][C@@H:37]([NH:44][C:19]([C:4]3[CH:5]=[C:6]([C:9]4[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=4)[CH:7]=[CH:8][C:3]=3[O:2][CH3:1])=[O:20])[C:38]3[O:42][N:41]=[C:40]([CH3:43])[N:39]=3)=[CH:32][CH:31]=2)[CH:26]=[CH:27][C:28]=1[F:29]

Participants

Reactant 2

HCID 68869955HCID 68869955, compound

HCID 86032170HCID 86032170, compound

Product 1

HCID 57717940HCID 57717940, compoundYield 90.2%

Procedure

4-Methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (55 mg) was prepared from 4-Methoxy-4′-trifluoromethyl-biphenyl-3-carbonyl chloride (31 mg, 0.1 mmol) and 2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (40 mg, 0.12 mmol) following the general procedure M.

Sources & evidence

ORD record: ord-9311bc0954e045f8a693068b35c29195
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

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