HCID 68869955, compound → HCID 57717996, compound

HRID 2373802Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C@@H:16]([NH2:23])[C:17]3[O:21][N:20]=[C:19]([CH3:22])[N:18]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[CH2:24]([O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:36]=[C:35]([C:43]([F:46])([F:45])[F:44])[CH:34]=2)=[CH:29][C:28]=1[C:47](O)=[O:48])[CH3:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C@@H:16]([NH:23][C:47]([C:28]3[CH:29]=[C:30]([C:33]4[CH:34]=[C:35]([C:43]([F:44])([F:45])[F:46])[CH:36]=[C:37]([C:39]([F:40])([F:42])[F:41])[CH:38]=4)[CH:31]=[CH:32][C:27]=3[O:26][CH2:24][CH3:25])=[O:48])[C:17]3[O:21][N:20]=[C:19]([CH3:22])[N:18]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 68869955HCID 68869955, compound

HCID 86032173HCID 86032173, compound

Product 1

HCID 57717996HCID 57717996, compoundYield 82.4%

Procedure

4-Ethoxy-3′,5′-bis-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (57 mg) was prepared from 2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (33 mg, 0.10 mmol) and 4-Ethoxy-3′,5′-bis-trifluoromethyl-biphenyl-3-carboxylic acid (37 mg, 0.1 mmol) following the general procedure A.

Sources & evidence

ORD record: ord-c7bbdec1f3624698ab04a417156ba175
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

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