HCID 68869955, compound → HCID 59852604, compound

HRID 2373804Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C@@H:16]([NH2:23])[C:17]3[O:21][N:20]=[C:19]([CH3:22])[N:18]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].Cl[C:25]([C:27]1[CH:28]=[C:29]([C:37]2[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][CH:38]=2)[CH:30]=[CH:31][C:32]=1[O:33][C:34](=[O:36])[CH3:35])=[O:26]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C@@H:16]([NH:23][C:25]([C:27]3[CH:28]=[C:29]([C:37]4[CH:42]=[CH:41][C:40]([C:43]([F:44])([F:46])[F:45])=[CH:39][CH:38]=4)[CH:30]=[CH:31][C:32]=3[O:33][C:34](=[O:36])[CH3:35])=[O:26])[C:17]3[O:21][N:20]=[C:19]([CH3:22])[N:18]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 68869955HCID 68869955, compound

HCID 86032175HCID 86032175, compound

Product 1

HCID 59852604HCID 59852604, compoundYield 70.5%

Procedure

Acetic acid 3-[2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylcarbamoyl]-4′-trifluoromethyl-biphenyl-4-yl ester (45 mg) was prepared from 2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (33 mg, 0.1 mmol) and acetic acid 3-chlorocarbonyl-4′-trifluoromethyl-biphenyl-4-yl ester (34 mg, 0.1 mmol) following the general procedure M.

Sources & evidence

ORD record: ord-8564237c8f7a4d9e804d7a72fd4c0004
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

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