HRID2373809

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(-c2ccc([N+](=O)[O-])cc2)cc1C(=O)O

HCID69205199

未命名化合物

结构：Cc1noc([C@H](N)Cc2ccc(-c3ccc(F)c(Cl)c3)cc2)n1.Cl

HCID69207955

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccc([N+](=O)[O-])cc2)cc1C(=O)N[C@H](Cc1ccc(-c2ccc(F)c(Cl)c2)cc1)c1nc(C)no1

HCID86597142

未命名化合物

收率 69.7%

PROCEDURE

实验过程

4-Methoxy-4′-nitro-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (0.045 g) was prepared from 4-Methoxy-4′-nitro-biphenyl-3-carboxylic acid (0.03 g, 0.11 mmol) and 2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine hydrochloride salt (0.04 g, 0.11 mmol) following general procedure A

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e7bb4968322e409dba4a7f158513b380
来源数据集: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07459472B2
来源说明: uspto-grants-2008_12

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][C:4]=1[C:18]([OH:20])=O.Cl.[Cl:22][C:23]1[CH:24]=[C:25]([C:30]2[CH:35]=[CH:34][C:33]([CH2:36][C@@H:37]([NH2:44])[C:38]3[O:42][N:41]=[C:40]([CH3:43])[N:39]=3)=[CH:32][CH:31]=2)[CH:26]=[CH:27][C:28]=1[F:29]>>[Cl:22][C:23]1[CH:24]=[C:25]([C:30]2[CH:35]=[CH:34][C:33]([CH2:36][C@@H:37]([NH:44][C:18]([C:4]3[CH:5]=[C:6]([C:9]4[CH:10]=[CH:11][C:12]([N+:15]([O-:17])=[O:16])=[CH:13][CH:14]=4)[CH:7]=[CH:8][C:3]=3[O:2][CH3:1])=[O:20])[C:38]3[O:42][N:41]=[C:40]([CH3:43])[N:39]=3)=[CH:32][CH:31]=2)[CH:26]=[CH:27][C:28]=1[F:29]