HCID 68869955, compound → HCID 86597143, compound

HRID 2373815Notes

Reaction equation

[Cl:1][C:2]1[C:3]([O:21][CH3:22])=[C:4]([C:18](O)=[O:19])[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:7]=1.[Cl:23][C:24]1[CH:25]=[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37][C@@H:38]([NH2:45])[C:39]3[O:43][N:42]=[C:41]([CH3:44])[N:40]=3)=[CH:33][CH:32]=2)[CH:27]=[CH:28][C:29]=1[F:30]>>[Cl:23][C:24]1[CH:25]=[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37][C@@H:38]([NH:45][C:18]([C:4]3[CH:5]=[C:6]([C:8]4[CH:9]=[CH:10][C:11]([C:14]([F:15])([F:16])[F:17])=[CH:12][CH:13]=4)[CH:7]=[C:2]([Cl:1])[C:3]=3[O:21][CH3:22])=[O:19])[C:39]3[O:43][N:42]=[C:41]([CH3:44])[N:40]=3)=[CH:33][CH:32]=2)[CH:27]=[CH:28][C:29]=1[F:30]

Participants

Reactant 2

HCID 68869955HCID 68869955, compound

HCID 69205100HCID 69205100, compound

Product 1

HCID 86597143HCID 86597143, compoundYield 64.7%

Procedure

5-Chloro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide (0.5 g) was prepared from 5-Chloro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (0.4 g, 1.2 mmol) and 2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (0.4 g, 1.2 mmol) according to the general procedure A.

Sources & evidence

ORD record: ord-d3abe506946a4dcebf39604027bc4072
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

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