反应详情

Acetic acid 5′-[2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylcarbamoyl]-4-trifluoromethyl-[1,1 ′;3′,1″]terphenyl-4′-yl ester (0.04 g ) was prepared from Acetic acid 5′-chlorocarbonyl-4-trifluoromethyl-[1,1′;3′,1″]terphenyl-4′-yl ester (0.06 g, 0.14 mmol) [prepared from 4′-Hydroxy-4-trifluoromethyl-[1,1′;3′,1″]terphenyl-5′-carboxylic acid following general procedures K & L.] and 2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (0.047 g,0.14 mmol) following general procedure M.