反应详情

Pyridinium dichromate (0.25 g, 0.67 mmol ) was added to a solution of 5-Fluoro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carbaldehyde (0.2 g, 0.67 mmol) DMF (2 mL) and stirred for 12 h, to complete the reaction more pyridinium dichromate (0.2 g , 0.53 mmol) was added and stirred for 12 h. The reaction mixture was diluted with water (5 mL) and extracted with EtOAc(10 mL). Solvent was removed under reduced pressure to get 5-Fluoro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (0.12 g).

1. additionwas added
2. stirringstirred for 12 h
3. extractionextracted with EtOAc(10 mL)
4. customSolvent was removed under reduced pressure