HCID 68869955, compound → HCID 86597148, compound

HRID 2373821Notes

Reaction equation

[F:1][C:2]1[C:3]([O:21][CH3:22])=[C:4]([C:18]([OH:20])=O)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:7]=1.[Cl:23][C:24]1[CH:25]=[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37][C@@H:38]([NH2:45])[C:39]3[O:43][N:42]=[C:41]([CH3:44])[N:40]=3)=[CH:33][CH:32]=2)[CH:27]=[CH:28][C:29]=1[F:30]>>[Cl:23][C:24]1[CH:25]=[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37][C@@H:38]([NH:45][C:18]([C:4]3[CH:5]=[C:6]([C:8]4[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=4)[CH:7]=[C:2]([F:1])[C:3]=3[O:21][CH3:22])=[O:20])[C:39]3[O:43][N:42]=[C:41]([CH3:44])[N:40]=3)=[CH:33][CH:32]=2)[CH:27]=[CH:28][C:29]=1[F:30]

Participants

Reactant 2

HCID 68869955HCID 68869955, compound

HCID 69204766HCID 69204766, compound

Product 1

HCID 86597148HCID 86597148, compound

Procedure

5-Fluoro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide was prepared from 5-Fluoro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (0.06 g, 0.19 mmol) and 2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (0.063 g, 0.19 mmol) following general procedure A.

Sources & evidence

ORD record: ord-5b68262fcb994992a044d0561acd9353
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

Loading…