HRID2373821

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1noc([C@H](N)Cc2ccc(-c3ccc(F)c(Cl)c3)cc2)n1

HCID68869955

未命名化合物

结构：COc1c(F)cc(-c2ccc(C(F)(F)F)cc2)cc1C(=O)O

HCID69204766

未命名化合物

PRODUCTS

生成物

结构：COc1c(F)cc(-c2ccc(C(F)(F)F)cc2)cc1C(=O)N[C@H](Cc1ccc(-c2ccc(F)c(Cl)c2)cc1)c1nc(C)no1

HCID86597148

未命名化合物

PROCEDURE

实验过程

5-Fluoro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-amide was prepared from 5-Fluoro-4-methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid (0.06 g, 0.19 mmol) and 2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (0.063 g, 0.19 mmol) following general procedure A.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5b68262fcb994992a044d0561acd9353
来源数据集: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07459472B2
来源说明: uspto-grants-2008_12

反应 SMILES

[F:1][C:2]1[C:3]([O:21][CH3:22])=[C:4]([C:18]([OH:20])=O)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:7]=1.[Cl:23][C:24]1[CH:25]=[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37][C@@H:38]([NH2:45])[C:39]3[O:43][N:42]=[C:41]([CH3:44])[N:40]=3)=[CH:33][CH:32]=2)[CH:27]=[CH:28][C:29]=1[F:30]>>[Cl:23][C:24]1[CH:25]=[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37][C@@H:38]([NH:45][C:18]([C:4]3[CH:5]=[C:6]([C:8]4[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=4)[CH:7]=[C:2]([F:1])[C:3]=3[O:21][CH3:22])=[O:20])[C:39]3[O:43][N:42]=[C:41]([CH3:44])[N:40]=3)=[CH:33][CH:32]=2)[CH:27]=[CH:28][C:29]=1[F:30]