4-Nitrophenylboronic acid → HCID 11189942, compound

HRID 2373829Notes

Reaction equation

HRID 2373829 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13]([C:15]2[C:24]([OH:25])=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)=[O:14])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[N+:26]([C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1)([O-:28])=[O:27]>>[CH3:9][O:8][C:7]1[C:2]([C:32]2[CH:33]=[CH:34][C:29]([N+:26]([O-:28])=[O:27])=[CH:30][CH:31]=2)=[CH:3][C:4]([CH2:10][CH2:11][NH:12][C:13]([C:15]2[C:24]([OH:25])=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)=[O:14])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 27735524-Nitrophenylboronic acidHCID 69208936HCID 69208936, compound

Product 1

HCID 11189942HCID 11189942, compoundYield 61%

Procedure

The title compound (27 mg) was prepared from 0.05 g (0.1 mmol) of resin-bound N-2-(3-bromo-4-methoxyphenyl)ethyl-3-hydroxyl-2-naphthamide and 50.0 mg (0.3 mmol) of 4-nitro-phenyl boronic acid as described in Example 110.

Sources & evidence

ORD record
ord-b5a0b4cb200f4505842044a432945e65
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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