5-Bromosalicylic acid → HCID 69208031, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-2-hydroxy-benzoic acid (2.21 g, 10 mmol), butyl bromide (3.46 g, 25 mmol), potassium carbonate (2.76 g, 20 mmol) and DMF (20 mL) was heated at 100° C. for 1 h. The reaction mixture was partitioned between ether (120 mL) and brine (100 mL). Ether layer was separated and washed again with brine (100 mL), dried over MgSO4. Purification by flash chromatography (ethyl acetate/hexanes 1:99, 1:19, 1:9) gave 5-Bromo-2-butoxy-benzoic acid butyl ester as yellow oil (1.648 g, 5.01 mmol).

Provenance & Evidence