Sodium Carbonate → HCID 69205065, compound

Participants

Reaction Conditions

Reaction Steps

2-(S)-[(4-Butoxy-3′-chloro-4′-fluoro-biphenyl-3-carbonyl)-amino]-3-(3′-trifluoromethyl-biphenyl-4-yl)-propionic acid methyl ester was prepared following General Procedure D using 3-(4-bromo-phenyl)-2-(S)-[(4-Butoxy-3′-chloro-4′-fluoro-biphenyl-3-carbonyl)-amino]-propionic acid methyl ester ((0.677 g, 1.19 mmol), 3-trifluoromethyl-benzene boronic acid (0.349 g, 1.8 mmol), palladium tetrakis-triphenylphosphine (69 mg, 0.06 mmol), and Na2CO3(aq) (2.0 N, 5 mL, 10 mmol) in DME (10 mL). The mixture was heated at 76° C. for 19 h. Purification by flash chromatography (ethyl acetate/hexanes 1:5, 1:4) gave the methyl ester of the title compound (177 mg, 0.28 mmol).

Provenance & Evidence