HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 2-(S)-(2-Benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 3-Biphenyl-4-yl-(2S)-(5-bromo-2-hydroxy-benzoylamino)-propionic acid methyl ester | HCID 69204773 | — |
| Product | 2-(S)-(2-Benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid methyl ester | HCID 69206371 | 45.6% |
Reaction Steps
2-(S)-(2-Benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid methyl ester (82 mg) was prepared from 3-biphenyl-4-yl-2-(S)-(5-bromo-2-hydroxy-benzoylamino)-propionic acid methyl ester (150 mg, 0.33 mmol) and benzyl bromide (0.047 mL, 0.40 mmol) as described in general procedure G and purified over silica gel (7:3, DCM-hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459472B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-2d118f04bf5e4838a3b7f384f3ee9eb6 |
| Source note | uspto-grants-2008_12 |