HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2373841Generated: October 30, 2026
Lithium Hydroxide → 2-(S)-(2-benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid
https://huagongshe.com/reaction/2373841
Participants
| Role | Name | HCID | Charge |
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| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2-(S)-(2-Benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid methyl ester | HCID 69206371 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 2-(S)-(2-benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid | HCID 59852596 | 69.7% |
Reaction Steps
2-(S)-(2-Benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid methyl ester (50 mg, 0.092 mmol) was dissolved in 5 mL of THF-MeOH (4-1), cooled to 0° C. and 1.1 equiv of 2 N LiOH added. After 30 minutes, 3.3 additional equiv of 2N LiOH was added and the reaction stirred for 60 minutes. The reaction was worked up according to general procedure C to give 2-(S)-(2-benzyloxy-5-bromo-benzoylamino)-3-biphenyl-4-yl-propionic acid (34 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07459472B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-0a7a4359c8c249c7950b6477cf847d7c |
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| Source note | uspto-grants-2008_12 |
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