3,5-Bis(benzyloxy)-alpha-chlorotoluene → [2-(3,4-Bis-benzyloxy-benzyloxy)-5-bromo-benzoylamino]-propionic acid methyl ester

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Reaction Steps

3-Biphenyl-4-yl-2-S)-[2-(3,4-bis-benzyloxy-benzyloxy)-5-bromo-benzoylamino]-propionic acid methyl ester (340 mg) was prepared from 3-biphenyl-4-yl-2-(S)-(5-bromo-2-hydroxy-benzoylamino)-propionic acid methyl ester (400 mg, 0.92 mmol) (See example 136) and 1,2-bis-benzyloxy-4-chloromethyl-benzene (374 mg, 1.1 mmol) as described in general procedure G and purified over silica gel (8:2, DCM-hexanes).

Provenance & Evidence