HCID 68869262, compound → HCID 59852563, compound

HRID 2373847Notes

Reaction equation

HRID 2373847 reaction equation
Cl[C:2]([C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:7]=[CH:8][C:9]=1[O:10][C:11](=[O:13])[CH3:12])=[O:3].[CH3:24][O:25][C:26](=[O:44])[C@@H:27]([NH2:43])[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[C:37]([Cl:42])[CH:36]=2)=[CH:31][CH:30]=1>>[CH3:24][O:25][C:26](=[O:44])[C@@H:27]([NH:43][C:2]([C:4]1[CH:5]=[C:6]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([F:22])([F:23])[F:21])=[CH:18][CH:19]=2)[CH:7]=[CH:8][C:9]=1[O:10][C:11](=[O:13])[CH3:12])=[O:3])[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[C:37]([Cl:42])[CH:36]=2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 68869262HCID 68869262, compoundHCID 86032175HCID 86032175, compound

Product 1

HCID 59852563HCID 59852563, compoundYield 90.6%

Procedure

2-(S)-[(4-Acetoxy-4′-trifluoromethyl-biphenyl-3-carbonyl)-amino]-3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-propionic acid methyl ester (278 mg) was prepared from acetic acid 3-chlorocarbonyl-4′-trifluoromethyl-biphenyl-4-yl ester (171 mg, 0.5 mmol) and 2-(S)-amino-3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-propionic acid methyl ester (155 mg, 0.5 mmol) following the general procedure M.

Sources & evidence

ORD record
ord-b3141d7679db46ba99a21d73607ffbb0
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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