HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → Methyl 5-(bromomethyl)pyrazine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Pyrazinecarboxylic acid, 5-methyl-, methyl ester | HCID 465065 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Methyl 5-(bromomethyl)pyrazine-2-carboxylate | HCID 21973569 | 29.6% |
Reaction Steps
To a solution of 5-methyl-pyrazine-2-carboxylic acid methyl ester (2.0 g, 13.146 mmol) in CCl4 (25 mL0 was added NBS (2.57 g, 14.461 mmol) and benzoyl peroxide (0.318 g, 1.314 mmol) and the solution was heated at 70 C. for 1 h. Upon cooling to RT, the organic layer was washed with NaHCO3, water, dried (Na2SO4), and concentrated under reduced pressure to give 0.900 g 5-Bromomethyl-pyrazine-2-carboxylic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459472B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-943813d9e5094dcda8d8d0ea79ce405a |
| Source note | uspto-grants-2008_12 |