4-Fluorobenzaldehyde → 4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}benzaldehyde

HRID 2373859Notes

Reaction equation

HRID 2373859 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[OH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=1>>[F:20][C:17]([F:18])([F:19])[C:14]1[CH:15]=[CH:16][C:11]([O:10][C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)=[N:12][CH:13]=1

Participants

3

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 178516044HCID 178516044, compound

Product 1

HCID 269857004-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}benzaldehyde

Procedure

4-(5-Trifluoromethyl-pyridin-2-yloxy)-benzaldehyde was prepared from 4-fluorobenzaldehyde (2.48 g, 20 mmol) and 2-hydroxy-5-trifluoromethylpyridine (3.29 g, 20 mmol) following general procedure B. (4.62 g)

Sources & evidence

ORD record
ord-8fc1bef8c49e471d99246584b65bb874
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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