HCID 59852762, compound → HCID 59852742, compound

HRID 2373873Notes

Reaction equation

HRID 2373873 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]([C:26]2[C:31](Cl)=[N:30][CH:29]=[CH:28][N:27]=2)[NH:16][C:17](=O)[CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC1C=C(C(NC(C2CCC2)=O)C2C(Cl)=NC=C[N:49]=2)C=CC=1)C1C=CC=CC=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:16]=[C:17]([CH2:18][CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[N:27]3[CH:28]=[CH:29][N:30]=[C:31]([NH2:49])[C:26]=23)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 59852762HCID 59852762, compoundHCID 59852816HCID 59852816, compound

Product 1

HCID 59852742HCID 59852742, compound

Procedure

N-[(3-Benzyloxyphenyl)-(3-chloropyrazin-2-yl)-methyl]-2-cyclohexyl-acetamide: Prepared according to the procedures for Cyclobutanecarboxylic Acid [(3-benzyloxy-phenyl)-(3-chloro-pyrazin-2-yl)-methyl]Amide, White solid, 1H NMR (CDCl3, 400 MHz) δ 0.88-0.97 (m, 2H), 1.09-1.29 (m, 3H), 1.63-1.82 (m, 6H), 2.11 (d, 1H, J=7.2 Hz), 5.02 (s, 2H), 6.55 (d, 1H, J=7.6 Hz), 6.86-6.94 (m, 3H), 7.03 (d, 1H, J=7.6 Hz), 7.19-7.25 (m, 1H), 7.30-7.40 (m, 6H), 8.32 (d, 1H, J=2.0 Hz), 8.49 (d, 1H, J=2.0 Hz).

Sources & evidence

ORD record
ord-e2285425a19d454caf5b095b875d4ef9
Source dataset
uspto-grants-2008_12
Patent number
US07459554B2

Reaction notes

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