HCID 11431851, compound → HCID 11598116, compound

HRID 2373922Notes

Reaction equation

[NH2:1]C1C2N(C([C@H]3CC[C@H](C(N)=O)CC3)=NC=2C2C=CC=C(OCC3C=CC=CC=3)C=2)C=CN=1.C[O:35][C:36]([CH:38]1[CH2:43][CH2:42][CH:41]([C:44]2[N:48]3[CH:49]=[CH:50][N:51]=[C:52]([NH2:53])[C:47]3=[C:46]([C:54]3[CH:59]=[CH:58][CH:57]=[C:56]([O:60][CH2:61][C:62]4[C:67]([F:68])=[CH:66][CH:65]=[CH:64][C:63]=4[F:69])[CH:55]=3)[N:45]=2)[CH2:40][CH2:39]1)=O>>[NH2:53][C:52]1[C:47]2[N:48]([C:44]([CH:41]3[CH2:42][CH2:43][CH:38]([C:36]([NH2:1])=[O:35])[CH2:39][CH2:40]3)=[N:45][C:46]=2[C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([O:60][CH2:61][C:62]3[C:67]([F:68])=[CH:66][CH:65]=[CH:64][C:63]=3[F:69])[CH:55]=2)[CH:49]=[CH:50][N:51]=1

Participants

Reactant 2

HCID 11431851HCID 11431851, compound

HCID 178508468HCID 178508468, compound

Product 1

HCID 11598116HCID 11598116, compound

Procedure

The procedures for trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid amide were applied to 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid methyl ester to afford the title compound; MS (ES+): m/z 478.02 [MH+].

Sources & evidence

ORD record: ord-6d8378c50e1145c8b7ea70ec258297bb
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459554B2

Reaction notes

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