HCID 11271536, compound → 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid methylamide

HRID 2373923Notes

Reaction equation

HRID 2373923 reaction equation
[CH3:1][NH:2]C([C@H]1CC[C@H](C2N3C=CN=C(N)C3=C(C3C=CC=C(OCC4C=CC=CC=4)C=3)N=2)CC1)=O.[NH2:35][C:36]1[C:37]2[N:38]([C:42]([CH:61]3[CH2:66][CH2:65][CH:64]([C:67](O)=[O:68])[CH2:63][CH2:62]3)=[N:43][C:44]=2[C:45]2[CH:50]=[CH:49][CH:48]=[C:47]([O:51][CH2:52][C:53]3[C:58]([F:59])=[CH:57][CH:56]=[CH:55][C:54]=3[F:60])[CH:46]=2)[CH:39]=[CH:40][N:41]=1>>[CH3:1][NH:2][C:67]([CH:64]1[CH2:63][CH2:62][CH:61]([C:42]2[N:38]3[CH:39]=[CH:40][N:41]=[C:36]([NH2:35])[C:37]3=[C:44]([C:45]3[CH:50]=[CH:49][CH:48]=[C:47]([O:51][CH2:52][C:53]4[C:58]([F:59])=[CH:57][CH:56]=[CH:55][C:54]=4[F:60])[CH:46]=3)[N:43]=2)[CH2:66][CH2:65]1)=[O:68]

Participants

3

Reactant 2

HCID 11271536HCID 11271536, compoundHCID 178485734HCID 178485734, compound

Product 1

HCID 598528104-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid methylamide

Procedure

The amide coupling procedures applied to the synthesis of (trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid methylamide was applied to 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid to afford the title compound; MS (ES+): m/z 492.12 [MH+].

Sources & evidence

ORD record
ord-07a319d5c6124a0cb94aec9647074611
Source dataset
uspto-grants-2008_12
Patent number
US07459554B2

Reaction notes

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