反应详情

温度

0 °C

To a solution of 15 g (73.9 mmol) 5-bromo-2-fluorobenzaldehyde in diethyl ether (100 ml) at 0° C. were slowly added 27.1 ml (81.3 mmol) of ethyl magnesium bromide solution (3 M in diethyl ether). After stirring at 0° C. for 3 h, water (20 ml) was carefully added upon which a white precipitate formed. The solid was filtered off and washed with tert-butylmethyl ether. The combined filtrates were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The crude title compound thus obtained (16.1 g, 93% of th.) was used in the next step without further purification.

1. customat 0° C.
2. customformed
3. filtrationThe solid was filtered off
4. washwashed with tert-butylmethyl ether
5. washThe combined filtrates were washed with brine
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated under reduced pressure