Ethanol → HCID 59852904, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-(2-amino-4-(2-fluoro-4-nitrophenoxy)pyridin-3-yl)phenyl)acetamide (32 mg, 0.086 mmol), DMF (1 mL), EtOH (1 mL) and H2O (1 mL) was treated with Fe powder (67 mg, 1.2 mmol), and NH4Cl (128 mg, 2.4 mmol) and the mixture heated at 100° C. for 20 min. The mixture was filtered through Celite®, the pH of the filtrate adjusted to pH 7 using phosphate buffer and then the mixture was extracted with EtOAc. The organic extract was dried (MgSO4) and concentrated to give the desired product (20 mg, 67%) as a yellow-brown solid. MS(ESI+): m/z 353.32 (M+H)+.

Provenance & Evidence