4-Nitro-3-trifluoromethylphenol → 2-Amino-5-hydroxybenzotrifluoride

Participants

Reaction Steps

A solution of 4-nitro-3-(trifluoromethyl)phenol (Aldrich, 414 mg, 2.0 mmol) in 10 mL of MeOH was added 10% Pd/C (100 mg). The suspension was stirred under H2 atmosphere for 12 h and it was then filtered and concentrated in vacuo to give 4-amino-3-(trifluoromethyl)phenol (350 mg, 95% yield), which was sufficiently pure to use in the next step. MS(ESI+): m/z 178.02 (M+H)+.

Provenance & Evidence