Acetonitrile → N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide

HRID 2374049Notes

Reaction equation

HRID 2374049 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[O:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8](C(N)=O)[CH:7]=1.C(#[N:27])C>>[NH2:27][C:8]1[CH:7]=[C:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:2]([F:1])[CH:3]=2)[CH:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 598530604-(3-Fluoro-4-pivalamidophenoxy)picolinamide

Product 1

HCID 59852964N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamideYield 70%

Procedure

Prepared in a manner similar to that which is described in Step A of Example 91. 4-(3-Fluoro-4-pivalamidophenoxy)picolinamide (110 mg, 0.33 mmol) in acetonitrile (4 mL) was converted to N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide (70 mg, 70% yield). MS(ESI+): m/z 304.21 (M+H)+.

Workup

  1. customPrepared in a manner similar to that which

Sources & evidence

ORD record
ord-ffc7c8ae89a04849b6067f634b5ff8f2
Source dataset
uspto-grants-2008_12
Patent number
US07459562B2

Reaction notes

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