HCID 59852848, compound → HCID 59853029, compound

HRID 2374093Notes

Reaction equation

HRID 2374093 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17](=[O:24])[CH2:18][C:19]([O:21]CC)=[O:20])=[C:11]([F:25])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.C(OC1C=CC(NC2N=CN=C(OC3C=CC(NC(=O)CC(NC4C=CC(F)=CC=4)=O)=CC=3F)C=2)=CC=1)C1C=CC=CC=1>>[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17](=[O:24])[CH2:18][C:19]([OH:21])=[O:20])=[C:11]([F:25])[CH:10]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 59852848HCID 59852848, compoundHCID 59853038N-(4-(6-(4-(Benzyloxy)phenylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide

Product 1

HCID 59853029HCID 59853029, compoundYield 18%

Procedure

Ethyl 3-(4-(2-aminopyridin-4-yloxy)-2,5-difluorophenylamino)-3-oxopropanoate (0.24 g, 0.68 mmol) was converted to the title compound (0.039 mg, 18%) in a manner similar to the preparation of Compound B of Example 116. HRMS(ESI+), Calcd.: 324.0796 (M+H)+, found: 324.0795 (M+H)+.

Sources & evidence

ORD record
ord-94cd7159daf34063b0010c854058cfd8
Source dataset
uspto-grants-2008_12
Patent number
US07459562B2

Reaction notes

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