Potassium Carbonate → HCID 69206618, compound

Participants

Reaction Steps

Potassium carbonate (0.56 g, 4.8 mmol) was added to a solution of 4-bromo-4′-hydroxybiphenyl (0.80 g, 3.2 mmol) in butanone (50 ml) with potassium iodide (0.1 g) as catalyst. This mixture was left stirring at room temperature for 10 min and a solution of 1-chloro-7,7-dimethyloctance from step 6 (0.50 g, 2.8 mmol) in butanone (10 ml) was added dropwise. The reaction mixture was heated under reflux for 44 h. The mixture was filtered and butanone was removed from the filtrate under reduced pressure. The product was extracted into ether (2×75 ml) and the combined ethereal extracts were washed successively with water, 5% sodium hydroxide and water, and dried (MgSO4). The solvent was removed in vacuo and the residue was purified by column chromatography [DCM] to give a white powder.

Provenance & Evidence