Potassium Hydroxide → HCID 69206624, compound

Participants

Reaction Steps

A solution of (4′-Bromobiphenyl-4-yl)hexyl toluene-p-sulphonate (2.50 g, 5.0 mmol) from step 2 in DMSO (50 ml) was cooled to −5° C. and potassium hydroxide powder (Fluka, 1.03 g, 0.018 mol) was added and the mixture was stirred using a mechanical stirrer, a solution of cyclobutylmethanol (0.80 g, 10.0 mmol) in DMSO (15 ml) was added dropwise. The reaction mixture was kept at −5° C. for 1 h and then removed from the cooling bath for a further 2 h. The product was extracted in hexane (150 ml) and washed with water in order to remove all traces of DMSO. Hexane was removed under reduced pressure and the residue was purified by column chromatography [DCM-hexane, 1:6] to give a white powder.

Provenance & Evidence