Sodium Carbonate → HCID 131727222, compound

Participants

Reaction Steps

4-Bromo-4′-[6-(cyclobutylmethoxy)hexyloxy]biphenyl (0.70 g, 1.7 mmol) from step 3 and a 2M-aqueous solution of sodium carbonate (40 ml) were mixed in DME (60 ml) and with tetrakis(triphenylphosphine)-palladium(0) (0.12 g, 0.12 mmol) under dry nitrogen; to which 2,3-difluoro-4-octyloxyphenylboronic acid (prepared as described in Example 1 step 4) (0.58 g, 2.0 mmol) was added. The stirred reaction mixture was heated under reflux overnight. The product was extracted into DCM and washed with brine, water and dried (MgSO4). The solvent was removed under reduced pressure and the residue was purified by column chromatography [DCM-hexane, 1:5] and recrystallised from hexane to give white crystals.

Provenance & Evidence