HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoacetate → 2-Methyl-5-(4-nitrophenyl)-1,3,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | Benzoic acid, 4-nitro-, hydrazide | HCID 3693744 | — |
| Product | 2-Methyl-5-(4-nitrophenyl)-1,3,4-oxadiazole | HCID 540416 | — |
Reaction Steps
4-Nitro-benzoic acid hydrazide (1.0 g, 5.6 mmol) was heated to reflux in trimethyl orthoacetate for 4 days. After cooling to RT, the mixture was triturated with hexanes and the title compound collected by filtration (0.93 g). MS (ESI+) for m/z 206 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462600B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-86c7c7543ed843c9830b697803f89bd2 |
| Source note | uspto-grants-2008_12 |