HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374152Generated: October 30, 2026
Benzophenone imine → HCID 86760778, compound
https://huagongshe.com/reaction/2374152
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzophenone imine | HCID 136809 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 3-Bromo-5-methoxy-4-methylpyridine | HCID 57363789 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86760778 | HCID 86760778 | — |
Reaction Steps
3-Bromo-5-methoxy-4-methylpridine (0.76 g) was placed in a single neck round bottom flask with NaOtBu (1.4 eq), BINAP (0.8 eq), Pd2(dba)3 (0.25 eq), and benzhydrylideneamine (1 eq) in toluene 20 ml, and refluxed at 150° C. for 4 h. The reaction was partitioned between water and EtOAc, and the EtOAc layer dried over Na2SO4. The product was purified by SGC (EtOAc/ Hexane) affording 5-methoxy-4-methyl-N-(diphenymethylene)pyridine-3-amine. MS (ESI+) for m/z 302 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07462600B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-4d6151c4ff2f4f8497c04453ce07e5fa |
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| Source note | uspto-grants-2008_12 |
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