1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 131731176, compound

Participants

Reaction Steps

11 (0.1 g, 0.070 mmol) was treated with 1% DBU in THF (3 mL) for 45 seconds at room temperature and the product was precipitated by 1 M HCl in diethyl ether (200 mL) then it was purified on a silica gel column using chloroform/methanol (7:1) to afford 12 (75 mg, 89%) as a white powder. ESI-MS (5 kV, MeOH): m/z (%)=1225.1 (100) [M+Na]+; HPLC (230 nm): >95%.

Provenance & Evidence